Malaria, which claims hundreds of thousands of lives each year — mainly children and especially in Africa -, is one of the leading causes of death by an infectious agent, the Plasmodium falciparum parasite. In research on malaria, the genetic mutation that causes sickle cell anemia (also known as drepanocytosis), a chronic disease that is often fatal in children under five, caught the attention of the scientific community very early on because it also provides protection against malaria.
Earlier emergence of malaria in Africa
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