Scientists have discovered that when a normal cellular cleanup process is disrupted, mice start behaving in ways that resemble human symptoms of autism spectrum disorder (ASD) and schizophrenia. They found that loss of normal autophagy influences how brain cells react to inhibitory signals from each other and contributes to the behavioral changes. This intricate signaling pathway could be a new therapeutic target for neurodevelopmental and neuropsychiatric disorders.
Protein pileup affects social behaviors through altered brain signaling
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