Scientists reported a novel molecular mechanism for the regulation of PCNA cycling during DNA replication. They proved that ATAD5-RLC opens PCNA ring to be removed from DNA as a bona-fide PCNA unloader. Since uncontrolled disassembly of replication machineries causes genomic instability that may result in cellular transformation, this study will be beneficial to develop strategies for cancer treatment.
An effective sweeper closes DNA replication cycling
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