Clostridiodes difficile infection has become a leading cause of severe, sometimes fatal diarrheal illness, with the bacterium’s toxins causing the damage. New work cements our knowledge of how C. diff’s two primary toxins, A and B, slip into intestinal cells, the first step toward a possible treatment that doesn’t involve antibiotics. This latest study, on toxin A, shows its activity can be blocked with molecules already being developed for various medical indications.
Sweet! How C. difficile toxin A enters intestinal cells
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