A small chemical change — shifting the position of two hydrogen atoms — makes the difference between mice that are healthy or that have insulin resistance and fatty liver, major risk factors for diabetes and heart disease. Making the change prevented the onset of these symptoms in mice fed a high-fat diet and reversed these prediabetes obese mice. Published in Science, the finding pinpoints a ‘druggable’ target that could be used to develop therapies for diabetes.
Tiny change has big effects, reverses prediabetes in mice
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