Researchers have uncovered new information regarding the effects of impaired expression of the gene SHMT2 in genetically modified mice. They found that suppression of SHMT2 expression of SHMT2 altered activity in metabolic pathways, which in turn inhibited growth and impaired mitochondrial respiration, which is a critical cellular function that has been linked to human aging and age-related illnesses. Activation of SHMT2 may have future potential as a treatment for age-related illness.
Slowing down — Is aging caused by decreased cellular metabolism?
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