Researchers have used a novel and first-of-its-kind newborn mouse model to study the effect of high oxygen concentrations, or hyperoxia, on lung development of newborn mice that are germ-free — meaning no microbes colonizing their lungs. Their goal is to learn how differences in the types of microbes that already colonize human lungs at birth — including extremely premature infants — can protect or make an infant more susceptible to life-threatening bronchopulmonary dysplasia, or BPD.
Germ-free lungs of newborn mice are partially protected against hyperoxia
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