Occam’s Razor and Its Ethical Implications in Eosinophilic Granulomatosis With Polyangiitis

The documentation of a case of eosinophilic granulomatosis with polyangiitis (EGPA) in the absence of serological evidence of that disorder1 raises fundamental issues regarding the amount of evidence required to validate a given provisional diagnosis. In this specific instance, robust histological evidence proved to be a valid alternative to serological evidence.1 In another report, in what was arguably the first reported case of pericardial effusion attributable to EGPA, the patient presented with asthma, pulmonary infiltrates, streaky hemoptysis, and iron deficiency in the absence of any abnormalities in the gastrointestinal tract, despite a positive test for fecal occult blood.