The reward pathway of the brain causes feelings of happiness but is also involved in behavioral disorders like schizophrenia and addiction. A breakthrough study has now identified the role of a protein called Npas4 in the reward pathway, mediated by the well-known proteins MAPK and CBP, opening doors to potential therapies for associated disorders. Cocaine-treated mice with inactivated Npas4 exhibited considerable reduction in cocaine-seeking behavior, emphasizing the relevance of the protein.
New protein function could be key to treatment of drug addiction and behavioral disorders
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