The FDA-approved drug liraglutide has been shown to help obese patients lose weight by suppressing their appetite. However, where and how the drug acts in the brain was not fully understood, until now. A new preclinical study shows how liraglutide crosses the brain’s blood barrier to engage with a region of the brainstem known as the nucleus tractus solitarius, which is responsible for balancing food intake and energy expenditure.
Newly discovered brain response to obesity drug may inform future treatments
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