The combined use of antiretroviral medications lopinavir and ritonavir, previously used to treat SARS-Cov-1 and MERS-Cov patients, appeared to cause bradycardia in 22% of elderly, critically ill COVID-19 patients, in a small study in France. Bradycardia was resolved in all patients after discontinuation or dose reduction of both medications.
Older, critically ill patients with COVID-19 may have increased risk of bradycardia with lopinavir and ritonavir
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