Researchers have identified an evolutionarily conserved pathway responsible for ‘closing down’ gene activity in the mammalian cell. The finding is closely related to the Polycomb pathway defined decades ago by a set of classic genetic experiments carried out in fruit flies. They repor the BAHCC1 protein is critically involved in silencing genes and acts as an integral component of the Polycomb gene-repressive pathway in mammalian cells.
‘BAH-code’ reader senses gene-silencing tag in cells
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