One of the most important protein signaling systems that controls neuronal guidance consists of the cell surface receptor ‘Robo’ and its cognate external guidance cue ‘Slit.’ The deficit of either of these proteins results in defects in brain structure and function. Researchers have now discovered the intricate molecular mechanism that allows the guidance receptor ‘Robo’ to react to signals in its environment, while avoiding premature activity that can lead to harmful outcomes.
Crystal-clear view of a key neuronal receptor opens door for new, targeted drugs
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