New discovery provides key to side effects caused by erectile dysfunction drugs

A new study reveals several features of PDE6 that were previously unseen. Included among them were some very promising regions of PDE6 that resemble fish-hooks and are responsible for controlling PDE activity. By targeting the fish-hook-like region with a new class of PDE inhibitors, drug development companies may be able to eliminate unwanted side effects of certain PDE targeting drugs.

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