The interaction between a chromosomal protein called HMGB1 and a cellular receptor called RAGE is known to trigger inflammation. Researchers have now used computer software to analyze structural similarities among existing drugs, and discovered that the popular anticonvulsant drug papaverine blocks the binding of HMGB1 to RAGE. The researchers conclude that papaverine can potentially be used to treat inflammation-related conditions, including sepsis and even cancer.
Using a common anticonvulsant to counteract inflammation
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