Scientists have discovered that a specific brain cell known as a ‘projection neuron’ has a central role to play in the brain changes seen in multiple sclerosis (MS). The research shows that projection neurons are damaged by the body’s own immune cells, and that this damage could underpin the brain shrinkage and cognitive changes associated with MS. These new findings provide a platform for specific new MS therapies that target damaged brain cells to be developed.
Cell types affected in brains of multiple sclerosis patients pinpointed
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