Neuropathic pain is a chronic condition resulting from nerve injury and is characterized by increased pain sensitivity. Although known to be associated with overly excitable neurons in the spinal cord, the mechanisms leading to chronic pain are poorly understood. Researchers have now shown that expression of a protein called FLRT3 in the spinal dorsal root ganglion causes pain sensitization, which can be alleviated by treatment with FLRT3-blocking antibodies.
Multi-tasking protein at the root of neuropathic pain
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