In a comparison of 0.25mg/kg and 0.40mg/kg doses of the newer and more convenient clot-busting medication tenecteplase, there was no advantage in increasing the dose above 0.25mg/kg in stroke patients who planned to have mechanical clot retrieval. In addition, administering tenecteplase may decrease the need for mechanical clot removal.
Lower dose of newer clot-buster may be appropriate for some stroke patients
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