About half of the people with multiple sclerosis have the HLA-DR15 gene variant. A study has now shown how this genetic predisposition contributes to the development of the autoimmune disease multiple sclerosis in combination with environmental factors. The decisive factor is the shaping of a repertoire of immune cells which – although they are effective in fighting off pathogens such as Epstein-Barr virus – also attack brain tissue.
Multiple sclerosis as the flip side of immune fitness
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