The ‘mismatch hypothesis’ argues that our bodies evolved to digest the foods that our ancestors ate, and that human bodies will struggle and largely fail to metabolize a radically new set of foods. This intuitive idea is hard to test directly, but the Turkana, a pastoralist population in remote Kenya, present a natural experiment: genetically homogenous populations whose diets stretch across a lifestyle gradient from relatively ‘matched’ to extremely ‘mismatched’ with their recent evolutionary history.
Obesity and disease tied to dramatic dietary changes
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