Researchers found that Langerhans cells (LCs) play a crucial role in mucocutaneous acute guest-versus-host disease (aGVHD). Their experiments in mice showed that when the LCs of a recipient were depleted, the formation of mucocutaneous lesions was enhanced because the infiltration of CD8+ T cells was inhibited. Their findings have significant implications for improving blood stem cell transplantation treatments and clinical outcomes for patients.
Langerhans cells are up to the job, they just need a chance
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