About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or ‘jumping genes,’ from hopping around the human genome. In cells with missing or mutated p53, the team found, retrotransposons move and multiply more than usual. The finding could lead to new ways of detecting or treating cancers with p53 mutations.
Cancer-fighting gene restrains ‘jumping genes’
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